Antibody–drug conjugates (ADCs) represent a rapidly evolving therapeutic modality, combining the selective targeting of monoclonal antibodies with highly potent small molecule payloads. Their inherent structural complexity demands a sophisticated and multi-faceted bioanalytical approach spanning preclinical discovery through late-stage clinical development. This white paper, developed by the ADC Working Group of the AAPS bioan...

The sustainability of global coffee production might be threatened by climate change and associated disease outbreaks, prompting the interest in underutilized wild Coffea species as reservoirs of genetic and chemical diversity. This study aimed to characterize the non-volatile chemical profiles and estimate genetic values for caffeine, trigonelline, and chlorogenic acid (CGA) of beans from 24 Coffea racemosa and 21 C. zangueba...

A molecular tool has been developed for the molecular identification of Ips sexdentatus (Börner 1776) (Coleoptera Curculionidae Scolytidae), the well-known six thooted bark beetle, widely distributed in Eurasia, where it infests several species of the genus Pinus and occasionally a few conifer species of the genera Abies , Larix and Picea . The developed test can be useful both in countries where I. sexdentatus is handled as a...