C. Robin results 392
· Newest (Page 1/16, per page 25)
Author: C. Robin ×Clear All Filters
Search Results
Jaguar Range‐Wide Connectivity: Prioritising Core Areas and Corridors Between and Within Protected Areas and Indigenous LandsNARA Subscribed
Anthropogenic habitat transformation has led to population declines and increasing isolation of populations of many species, particularly top predators, where small and fragmented populations often experience limited dispersal and reduced genetic diversity. Jaguars ( Panthera onca ), for example, have lost half of their historical range and most populations outside the Amazon biome are small, isolated and highly threatened. He...
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. This study investigates the genetic determinants of tobacco carcinogen metabolism among smokers, focusing on ancestry-informative markers (AIMs) near genes involved in metabolic activation (Phase I), detoxification (Phase II), and transport (Phase III) of tob...
Killer Whales in the Central Tropical Pacific: Occurrence, Resightings, Morphology, and AcousticsNARA Subscribed
Compared to their well‐studied coastal temperate counterparts, killer whales ( Orcinus orca ) in tropical‐subtropical and oceanic areas are under‐documented. We used sighting, photo‐identification, and acoustic data of killer whales in the central tropical Pacific (CTP), collected from multiple platforms between 2002 and 2023, to assess their temporal and spatial distribution, group dynamics and behavior, movements, pigmentati...
Pandemic Vibrio cholerae and the Environmental Reservoir Hypothesis—Outstanding Questions Central to Global Cholera ControlNARA Subscribed
Despite global cholera cases rising to more than 560,000 in 2024, there remains no consensus on a fundamental aspect of cholera epidemiology: whether pandemic Vibrio cholerae forms long‐term environmental reservoirs which become the source of future outbreaks. This knowledge gap prevents optimal disease forecasting, resource allocation and outbreak response in a variety of at‐risk settings, from places experiencing annual chol...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Heat-labile toxin (LT) from enterotoxigenic Escherichia coli (ETEC) is an important pathogenic protein. Anti-LT antibodies (Abs) induced by vaccination can neutralize the toxin and potentially prevent diarrheal secretion from ~ 60% of ETEC strains expressing LT. However, only superficial investigation of the anti-toxin response is usually conducted in clinical trials. Here, we utilized human serum samples from two clinical tri...