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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
A geological and geophysical database for the assessment of offshore freshened groundwater resourcesNARA Subscribed
Fresh groundwater resources in coastal regions are vital for modern society, but are under considerable pressure due to population growth, seasonal peaks in demand, pollution and climate change. In recent years, interest in offshore freshened groundwater (OFG) has surged, as potential resource for addressing these challenges. Recent studies have documented OFG occurrences on many continental margins and islands, with global vo...
Branchial localization of acid (A‐type) and base (B‐type) excreting ionocytes in Amazonian stenohaline freshwater Potamotrygon rayNARA Subscribed
The branchial epithelium of Potamotrygon —a member of the only strictly freshwater elasmobranch family Potamotrygonidae—was observed via immunohistochemistry, and two distinct forms of ionocytes were identified. The acid (A‐type) and base (B‐type) secreting cells with respective basolateral–apical localizations of Na + /K + ‐ATPase–Na + /H + exchanger 3 in A‐type and V‐type H + ‐ATPase–pendrin Cl − /HCO 3 − exchanger in B‐type...
The Marsupial Database: A comprehensive dataset on the ecology and life history of American and Australasian marsupialsNARA Subscribed
Marsupials are an important but typically neglected group of mammals that have been overlooked in many comparative analyses of vertebrate ecology and life history evolution. In order to address this knowledge bias, we have developed The Marsupial Database. The Marsupial Database contains traits for a phylogenetically diverse set of 414 extant and recently extinct (last 200 years) species from all seven modern marsupial orders...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...