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Managing and visualising geochemical data for tephra correlation with the IntChron Integration ToolNARA Subscribed
There is now a wealth of glass‐shard geochemical data for volcanic ash (tephra) layers from a wide range of volcanoes and eruptions, providing invaluable datasets for tephrochronology. However, compilation of published data to assess tephra correlations leads to large files and requires careful management. Here, we show that a project within the IntChron Integration Tool (Ramsey et al., 2019), an open‐access and versatile onli...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Gut dysfunction commonly precedes motor symptoms in Parkinson’s disease (PD), but the mechanistic sequence of gut versus brain pathology remains unclear. This work aimed to define the timing of intestinal barrier dysfunction relative to central nervous system (CNS) changes in the A53T α-synuclein transgenic mouse model of PD. Functional and molecular assessments of the gastrointestinal tract (ileum and colon) were conducted at...
Aim Aims of the study are to examine patterns of range‐wide genetic differentiation and population structure in a headwater obligate salamander living in a geologically rich region, to identify genetically distinct populations and areas of gene flow between them. Location Oregon and Washington in the Pacific Northwest, United States of America. Time Period Tissue samples were collected in 2022 and 2023. Major Taxa Studied The...
The El Zorro gold district is the most recent gold discovery in the Coastal Cordillera of northern Chile. Ternera is the largest deposit in the district with total resources currently estimated at 1.282 Moz. New geology, geochemistry and geochronology data indicate that hydrothermal mineralization is mostly hosted within felsic to intermediate, ilmenite-bearing calc-alkaline dikes and stocks of the Upper Triassic to Lower Jura...
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor developmentNARA Subscribed
Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant bone marrow conditions such a...
Dinoflagellates of the family Symbiodiniaceae are important symbionts of diverse marine animals and they also occupy different environmental niches on coral reefs. The link between diversity at ecosystem‐scale to microhabitats of Symbiodiniaceae within the coral holobiont is largely unknown. Using ITS2‐amplicon sequencing, we compared Symbiodiniaceae communities across four environments (seawater, near‐reef vs. distant sedimen...
This systematic review examines the prevalence, underlying mechanisms, cohort characteristics, evaluation criteria, and cohort types in white matter hyperintensity (WMH) pipeline and implementation literature spanning the last two decades. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we categorized WMH segmentation tools based on their methodologies from January 1, 2000, to...