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Key message A data mining strategy capitalizing on high-resolution SNP information, sequence variant annotation and QTL information from three populations facilitated an efficient nomination of candidate genes for YR resistance, supported by Yr27 and functional annotations. Abstract Genome-wide association studies (GWAS) have become routine in many crops, but the prioritization of candidate genes remains challenging. Here, we...
Forecasting the number of individuals entering a fishery is critical for sustainable harvest and thereby management actions, but it remains challenging due to the considerable inter‐annual variability and the complex nature of causal factors. This long‐standing ‘recruitment problem’ has become even more urgent under ongoing climate change and the associated regime shifts overturning traditional predictive models. Leveraging th...
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Pain responses following resistance exercise with and without blood flow restriction in individuals with multiple sclerosisNARA Subscribed
Purpose Pain is a common symptom among individuals living with multiple sclerosis (MS). Exercise-induced hypoalgesia (EIH), a reduction in pain sensitivity following resistance exercise, typically requires high loads. Blood flow restriction (BFR) training may offer a lower-load alternative to elicit EIH. This investigation aimed to assess EIH responses following resistance exercise with and without BFR in individuals with MS....
Through genomic phylogeography, previously unrecognised biodiversity can be revealed. The alpine newt serves as a case in point: this taxon carries highly distinct mtDNA clades and has a severely fragmented range. We obtain genome‐wide data with target enrichment by sequence capture to delineate cryptic species and disentangle their phylogenetic relationships. Furthermore, we explore potential niche divergence and glaciation‐d...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Trade‐offs are an inherent feature of organismal biology and fundamental to the evolution of natural populations. Here, we use experimental evolution in large, genetically diverse populations of Drosophila melanogaster to directly measure the manifestation of trade‐offs in response to fluctuating selection on ecological timescales. We first conducted a lab‐based selection experiment to quantify a genome‐wide signal of fluctuat...