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Freshwater mollusk shells serve as valuable archives for the reconstruction of past environmental conditions as they record water temperatures in their stable isotopic compositions during biomineralization. Yet, the impact of food availability on these isotopic records has never been fully explored. This study addresses that gap by investigating the effects of both temperature and food regime on the stable carbon (δ 13 C) and...
Ant foraging and recruitment often relies heavily on pheromone trails, and ants modulate pheromone trail deposition strategically. Ants are also known to modulate trail following depending on their own private information, such as the known location of the nest and their knowledge of food sources in the environment. Here we ask how a series of important context variables—distance from the nest, direction of travel, and prior f...
Expanding insights into plant rhabdovirus diversity through the discovery of viruses representing 32 putative novel speciesNARA Subscribed
Plant-infecting rhabdoviruses (family Rhabdoviridae , subfamily Betarhabdovirinae ) include several viruses that cause important crop diseases and are subject to phytosanitary regulation. Despite their agricultural and ecological importance, the diversity of plant rhabdoviruses and their impact on plant health remain poorly understood. Here, we report 32 tentative novel species of plant-infecting rhabdoviruses, identified via...
Antimicrobial resistance (AMR) poses a major global health challenge, and wildlife has increasingly been recognized as an important sentinel for monitoring the environmental circulation of clinically relevant resistant bacteria. In this study, we report the phenotypic, genomic, and phylogenomic characterization of a multidrug-resistant (MDR) Klebsiella pneumoniae isolate recovered from a free-ranging wild porcupine ( Coendou s...
Submarine landslides can generate tsunamis and pose risks to underwater infrastructure, but a lack of direct observations of such slides hinders our understanding of their development and hazard potential. Studying the morphology of past slides can offer insights into their preconditioning and failure. Here, new high‐quality 2D and 3D seismic data were used to determine, for the first time, the extent and morphology of the Sta...
Carbon dioxide activated biochars as mediators for reductive debromination of 1,2-dibromoethaneNARA Subscribed
The fuel additive and pesticide 1,2-dibromoethane (DBA) is a problematic organic pollutant found in soil and aquifers. Remediation methods face drawbacks because of undesirable by-products and slow rates of removal. Biochars (BCs) are catalysts of reductive dehalogenation in anoxic environments by the layered iron(II)-iron(III) hydroxide green rust (GR). However, so far, such catalytic properties have generally only been obser...
Seasonal and spatial transitions in phytoplankton assemblages spanning estuarine to open ocean waters of the tropical PacificNARA Subscribed
Islands in the tropical Pacific supply elevated nutrients to nearshore waters that enhance phytoplankton biomass and create hotspots of productivity in otherwise nutrient‐poor oceans. Despite the importance of these hotspots in supporting nearshore food webs, the spatial and temporal variability of phytoplankton enhancement and changes in the underlying phytoplankton communities across nearshore to open ocean systems remain po...
In humans, glucocorticoid resistance is attributed to mutations in the glucocorticoid receptor (GR). Most of these mutations result in decreased ligand binding, transactivation, and/or translocation, albeit with normal protein abundances. However, there is no clear genotype‒phenotype relationship between the severity or age at disease presentation and the degree of functional loss of the receptor. Previously, we documented tha...
Model-informed dose optimization of mycophenolic acid in pediatric kidney transplant patientsNARA Subscribed
Purpose We aimed to develop and evaluate a population PK model of mycophenolic acid (MPA) in pediatric kidney transplant patients to aid MPA dose optimization. Methods Data were collected from pediatric kidney transplant recipients from a Dutch academic hospital (Radboudumc, the Netherlands). Pharmacokinetic model-building and model-validation analyses were performed using NONMEM. Subsequently, we externally evaluated the fina...