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North Pacific humpback whales are a celebrated conservation success, rebounding from extensive commercial whaling. Yet they remain vulnerable to the impacts of climate change, a multifaceted stressor that can exacerbate existing threats. During 2013–2016, a Northeast Pacific marine heatwave severely reduced forage availability in their feeding grounds, concurrent with diminished whale recruitment and increased mortality. We an...
Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and SexNARA Subscribed
Purpose Prior studies report abnormal pulsatile arterial hemodynamics in hypertensives. Small patient numbers preclude determining whether and how those abnormalities are associated with pressure or sex. In a large population of young hypertensives, we examine these associations. Methods During catheterization, we acquired high-fidelity pressure and flow signals to calculate hemodynamic parameters: flow ( Q ), input resistance...
Antibody–drug conjugates (ADCs) represent a rapidly evolving therapeutic modality, combining the selective targeting of monoclonal antibodies with highly potent small molecule payloads. Their inherent structural complexity demands a sophisticated and multi-faceted bioanalytical approach spanning preclinical discovery through late-stage clinical development. This white paper, developed by the ADC Working Group of the AAPS bioan...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Extreme heat events have increased markedly over recent decades globally, with potentially severe impacts on soil carbon (C) cycling. Here, we conducted a mechanistic study to assess the impact of a single 3‐day extreme heat event (30°C, 40°C, 50°C) on C cycling in an arable soil in North Wales, exploring subsequent 200‐day potential legacy effects and shifts in microbial community structure. Soils exposed to 30°C or 40°C did...