Purpose of Review Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder characterized by hallucinations, delusions, paranoia, and anhedonia [1, 2]. Strong biological plausibility supports a disease-specific relationship between metal and metalloid exposures and SCZ, particularly through disruption of metal ion coordination within with the N-methyl-D-aspartate receptor (NMDAr), a key regulator of neurodevelopment and...

Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...

Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...

Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...

Metals are essential for microbial metabolism, yet their role as limiting nutrients in freshwater streams remains poorly understood. We quantified the prevalence of metal and nutrient (co‐)limitation of primary producers in 41 streams. Metal limitation was widespread with Fe limitation eliciting the strongest and most consistent biomass responses (50% of streams). Zn limitation was also common (33% of streams), marking the fir...

The ocean plays an essential role in regulating Earth’s climate, influencing weather conditions, providing sustenance for large populations, moderating anthropogenic climate change, encompassing massive biodiversity, and sustaining the global economy. Human activities are changing the oceans, stressing ocean health, threatening the critical services the ocean provides to society, with significant consequences for human well-be...

Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group‐level processes such as subgroup formation and fission–fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing coh...

Novel approaches are required to find new treatments for schizophrenia and other neuropsychiatric disorders. This study utilised a combination of in vitro transcriptomics and in silico analysis with the BROAD Institute’s Connectivity Map to identify drugs that can be repurposed to treat psychiatric disorders. Human neuronal (NT2-N) cells were treated with a combination of atypical antipsychotic drugs commonly used to treat psy...

More frequent and severe droughts are driving increased forest mortality around the globe. We urgently need to describe and predict how drought affects forest carbon cycling and identify thresholds of environmental stress that trigger ecosystem collapse. Quantifying the effects of drought at an ecosystem level is complex because dynamic climate–plant relationships can cause rapid and/or prolonged shifts in carbon balance. We e...

Motivation Aquatic insects comprise 64% of freshwater animal diversity and are widely used as bioindicators to assess water quality impairment and freshwater ecosystem health, as well as to test ecological hypotheses. Despite their importance, a comprehensive, global database of aquatic insect occurrences for mapping freshwater biodiversity in macroecological studies and applied freshwater research is missing. We aim to fill t...

Conservationists speculated on potential benefits to wildlife of lockdown restrictions because of the COVID-19 pandemic but voiced concern that restrictions impeded nature conservation. We assessed the effects of lockdown restrictions on biodiversity conservation in South Africa, a biodiverse country with economic inequality and reliance on wildlife resources. We solicited expert opinion using the IUCN’s Threats Classification...

Visible protein-like particle standards may improve visual inspection and/or appearance testing practices used in the biotechnology industry. They may improve assay performance resulting in better alignment and more standardized training among different companies. The National Institute of Standards and Technology (NIST) has conducted an interlaboratory study to test whether the standards under development mimic typical protei...

This is the second of three papers dealing with metal-bearing circumneutral mine drainage from the inactive Rico-Argentine mine site located at an elevation of ≈ 2740 m (9000 feet) in the San Juan mountain range in southwestern Colorado. This paper evaluates two years of mine drainage treatment using a passive system that included a vertical-flow engineered biotreatment cell. The collapsed St. Louis Tunnel (SLT) discharges cir...

Managing wildlife populations in the face of global change requires regular data on the abundance and distribution of wild animals, but acquiring these over appropriate spatial scales in a sustainable way has proven challenging. Here we present the data from Snapshot USA 2020, a second annual national mammal survey of the USA. This project involved 152 scientists setting camera traps in a standardized protocol at 1485 location...

Aim Macroecological studies that require habitat suitability data for many species often derive this information from expert opinion. However, expert‐based information is inherently subjective and thus prone to errors. The increasing availability of GPS tracking data offers opportunities to evaluate and supplement expert‐based information with detailed empirical evidence. Here, we compared expert‐based habitat suitability info...