Background Human Bocavirus 2 (HBoV2) is an emerging enteric virus frequently detected in wastewater, yet its environmental fate, persistence, and treatment remain poorly understood. Improved characterization of HBoV2 is important for advancing wastewater-based epidemiology and understanding viral transmission dynamics. Methods and Results A year-long wastewater surveillance study was conducted from December 2023 to December 20...

Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. This study investigates the genetic determinants of tobacco carcinogen metabolism among smokers, focusing on ancestry-informative markers (AIMs) near genes involved in metabolic activation (Phase I), detoxification (Phase II), and transport (Phase III) of tob...

Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...

The Amundsen Sea polynya hosts intense sea ice formation, but, due to the presence of relatively warm and salty modified Circumpolar Deep Water, the cold, brine-enriched water is not typically dense enough to sink to the deep ocean. A hydrographic survey of the Dotson Ice Shelf region in the Amundsen Sea using two ocean gliders identified and characterised subsurface lenses containing water with temperatures less than −1.70 °C...

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) may occur at least 10 years before a clinical diagnosis of an α-synucleinopathy, such as dementia with Lewy bodies (DLB), Parkinson’s disease (PD) or multiple system atrophy (MSA). The extent to which people with iRBD manifest subtle features of these conditions is an area of active research and whether these changes can be measured remotely in the community is a...

2022 marked the third consecutive La Niña and extended the longest consecutive stretch of negative Oceanic Niño Index since 1998-2001. While physical and biological conditions in winter and spring largely adhered to prior La Niña conditions, summer and fall were very different. Similar to past La Niña events, in winter and spring coastal upwelling was either average or above average, temperature average or below average, salin...