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Influence of Substrate Surface Morphology on Bonding Behaviours at Shotcrete–Substrate InterfaceNARA Subscribed
This study investigates the influence of substrate morphology on bond strength at the interface. Circular surfaces with varying morphologies were created on plaster substrates and quantified by three three-dimensional (3D) roughness parameters: joint roughness coefficient (JRC 3D ), area ratio ( R S ), and statistical parameter Z 2S . Plaster substrates were designed in a LEGO-style configuration, with various morphology surfa...
Detection of Cyclic Imines (CIs) Toxins in Whole Body of Shellfishes: First Monitoring Report of CIs in South Korea ShellfishesNARA Subscribed
Cyclic imines (CIs) produced by microalgal species that accumulate in the food chains of marine organisms are novel biotoxins that do not belong to the classic group of marine biotoxins. In the past, CIs were found only in limited areas; however, in recent years, rapid changes in marine ecosystems have led to widespread CIs and increased exposure to toxic risks. In this study, we analyzed seven CI toxins, GYM-A, SPX (13-desmet...
An Improved Model for Evaluating the Hydraulic Behaviour of a Single Rock Joint Considering Contact Area Evolution During ShearingNARA Subscribed
The contact of rock joints during shearing induced by underground excavation significantly impacts the hydro-mechanical behaviour of fractured rock mass, since fluid tends to flow through a rough-walled fracture along connected channels while bypassing the contact areas with tortuosity. However, previous research mostly considered joint roughness or aperture changes based on 2D joint profiles, while the contact and tortuosity...
Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as a proof-of-concept study to demonstrate efficacy of pazopanib on HHT-related bleeding, and to measure safety....
Comparative evaluation of MCP gene in worldwide strains of Megalocytivirus ( Iridoviridae family) for early diagnostic markerNARA Subscribed
Members of the Iridoviridae family have been considered as aetiological agents of iridovirus diseases, causing fish mortalities and economic losses all over the world. Virus identification based on candidate gene sequencing is faster, more accurate and more reliable than other traditional phenotype methodologies. Iridoviridae viruses are covered by a protein shell (capsid) encoded by the important candidate gene, major capsid...
Rock bream iridovirus ( RBIV ) causes huge losses, especially in rock bream Oplegnathus fasciatus . Rock bream injected with RBIV and held at 29, 26, 23 or 20 °C had 100% mortality. Conversely, all infected fish held at 17 °C survived even after the temperature was progressively increased to 26 °C at 100 dpi. Rock bream exposed to virus and held for 2, 4 and 7 days at 23/26 °C before the temperature was reduced to 17 °C had mo...