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Local drug delivery systems (LDDS) are a promising method to overcome challenges associated with chemotherapeutic treatment of brain tumours, namely poor blood-brain barrier penetration. Here we report a poly(ethyleneglycol)-poly(lactide)-poly(caprolactone)-poly(lactide)-poly(ethyleneglycol) based injectable hydrogel, PELCLE, loaded with Doxorubicin (Dox) and Olaparib (Ola) as an LDDS against glioblastoma (GBM), a primary mali...
Gait Retraining with Realtime Feedback May Reduce Pain and Improve Function in Runners: A Systematic ReviewNARA Subscribed
Purpose Running-related lower extremity injuries are common and often linked to modifiable biomechanical factors. Gait retraining (GR) using real-time feedback (RTF) has emerged as a potential intervention to alter running biomechanics and reduce pain, but the clinical effectiveness in injured runners has not been determined. The purpose of this study was to evaluate the effectiveness of GR with RTF on lower extremity pain and...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Extensive regional variation in the phenology of insects and their response to temperature across N orth A mericaNARA Subscribed
Climate change models often assume similar responses to temperatures across the range of a species, but local adaptation or phenotypic plasticity can lead plants and animals to respond differently to temperature in different parts of their range. To date, there have been few tests of this assumption at the scale of continents, so it is unclear if this is a large‐scale problem. Here, we examined the assumption that insect taxa...
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging are not well understood. To better understand mechanisms of muscle aging, we investigated the potential role of ATF4, a transcription regulatory protein that can rapidly promote skeletal muscle atrophy in young animals deprived of adequate nutrition or a...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Joint effects of climate, tree size, and year on annual tree growth derived from tree‐ring records of ten globally distributed forestsNARA Subscribed
Tree rings provide an invaluable long‐term record for understanding how climate and other drivers shape tree growth and forest productivity. However, conventional tree‐ring analysis methods were not designed to simultaneously test effects of climate, tree size, and other drivers on individual growth. This has limited the potential to test ecologically relevant hypotheses on tree growth sensitivity to environmental drivers and...
On the evolution of trophic positionNARA Subscribed
The trophic structure of food webs is primarily determined by the variation in trophic position among species and individuals. Temporal dynamics of food web structure are central to our understanding of energy and nutrient fluxes in changing environments, but little is known about how evolutionary processes shape trophic position variation in natural populations. We propose that trophic position, whose expression depends on bo...
The relationship between atmospheric circulation patterns and extreme temperature events in North AmericaNARA Subscribed
Extreme temperature events (ETEs) pose a significant risk to society, especially vulnerable populations with limited access to shelter and water and those with pre‐existing respiratory and cardiovascular ailments. This research examines the relationship of atmospheric circulation with a myriad of metrics related to ETEs to better understand which synoptic‐scale circulations are likely to have negative health/thermal comfort ou...
Examining trends in multiple parameters of seasonally‐relative extreme temperature and dew point events across North AmericaNARA Subscribed
Concurrent with the background rise in global mean temperatures, changes in extreme events are also becoming evident, and are arguably more impactful on society. This research examines trends in three components of seasonally‐relative extreme temperature and humidity events in North America that directly influence human thermal comfort: event frequency, duration, and areal extent. Results indicate that for the majority of the...