Baicalin, a bioactive flavonoid from Scutellaria baicalensis , shows significant therapeutic efficacy on tilapia ( Oreochromis niloticus ) bacterial infections, but its application remains limited due to the lack of pharmacokinetic data. In this study, single oral administration of baicalin at 12 mg/kg was carried out in O. niloticus under 32°C. Then, samples of plasma, kidney, bile, muscle, liver and brain were collected at v...

Among older adults with early breast cancer, the risk of chemotoxicity can vary widely despite similar chronological age. Here, we evaluated whether epigenetic indicators of biological age can stratify the risk of chemotoxicity in this population. In a prospective study of 394 women age > 65 with stage I–III breast cancer treated with neo/adjuvant chemotherapy, we analyzed peripheral blood DNA methylation patterns to estimate...