Sepsis and septic shock are major causes of global mortality. Analyzing trends in incidence, in-hospital mortality (IHM), and length of stay (LOS) is critical to improve patient outcomes. This retrospective study examined the impact of sepsis on patients admitted to St. Anna University Hospital in Ferrara, Italy, from 2003 to 2022. Inclusion criteria were patients aged ≥ 18, admitted through the Emergency Department with a con...

Sepsis is a life-threating organ dysfunction caused by a dysregulated host response to infection. This study proposed a new tool, i.e. modified qSOFA, for the early prognostic assessment of septic patients. All cases of sepsis/septic shock consecutively observed in 2 years (January 2017–December 2018), at St. Anna University Hospital of Ferrara, Italy, were included. Each patient was evaluated with qSOFA and a modified qSOFA (...

Panton-Valentine leukocidin (PVL) appears to be a virulence factor which, among others, can exacerbate the pathogenicity of Staphylococcus aureus infections, especially inducing severe necrotic, deep-seated skin infections, abscesses, and recurrences. These peculiarities have some overlaps with hidradenitis suppurativa (HS). Our main aim was to assess if S. aureus producing PVL could have some role in influencing clinical feat...