Carolin Peter results 28
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Weiss-Kruszka syndrome (WSKA; OMIM 618619) is a rare autosomal dominant neurodevelopmental disorder caused by haploinsufficiency of ZNF462, a zinc-finger transcription factor involved in chromatin regulation and early embryonic development. WSKA is characterized by developmental delay, hypotonia, craniofacial dysmorphic features (around 8) and variable congenital anomalies. Genome-wide DNAm profiling was performed on periphera...
Surface slicks structure microbial and viral neuston in relation to biogeochemical conditionsNARA Subscribed
The sea‐surface microlayer (hereafter microlayer), which forms the interface between the ocean and atmosphere, plays a key role in nutrient cycling and microbial dynamics. Coastal slicks, which are viscous and biogenic surface films, often serve as hotspots for microbial activity, yet their structure and interactions remain incompletely understood. Here, we investigated viral and microbial abundance, surfactants, dissolved org...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Salt marshes provide vital ecosystem services, including coastal protection and carbon sequestration. Roots play a key role in delivering these ecosystem services, as they stabilize soils and contribute to organic carbon accumulation. This study examines the impact of an experimental 3°C temperature increase in a temperate salt marsh on belowground biomass dynamics across three elevation zones (pioneer zone, low marsh, and hig...
Structural epilepsies display complex immune activation signatures. However, it is unclear which neuroinflammatory pathways drive pathobiology. Transcriptome studies of brain resections from mesial temporal lobe epilepsy (mTLE) patients revealed a dysregulation of transforming growth factor β, interferon α/β, and nuclear factor erythroid 2-related factor 2 pathways. Since these pathways are regulated by ubiquitin-specific prot...
Citizen science’s transformative impact on science, citizen empowerment and socio-political processesNARA Subscribed
Citizen science (CS) can foster transformative impact for science, citizen empowerment and socio-political processes. To unleash this impact, a clearer understanding of its current status and challenges for its development is needed. Using quantitative indicators developed in a collaborative stakeholder process, our study provides a comprehensive overview of the current status of CS in Germany, Austria and Switzerland. Our onl...
Pesticide residues in daily bee pollen samples (April–July) from an intensive agricultural region in Southern GermanyNARA Subscribed
Insect-pollinated plants are essential for honey bees to feed their brood. In agricultural landscapes, honey bees and other pollinators are often exposed to pesticides used for cultivation. In order to gain more insight into the fluctuation of pesticide loads, 102 daily pollen samples were collected between April and July 2018 in a fruit-growing area in Southern Germany. Samples were analyzed with respect to more than 260 pest...
TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nucleiNARA Subscribed
TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. However, its impact on TJs of ciliated epithelia is sparsely investigated. Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. We demonstrate that TGF-β1 activates TGF-β1 receptors TGFBR1 and TGFBR2 resulting in ALK5-mediated phosphorylation of SMAD2. We obse...