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NARA Subscribed1
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Springer Nature1
Journal
Human Genetics1
Publication Year
20211
Cary O. Harding results 1 · Newest (Page 1/1, per page 25)
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ASL expression in ALDH1A1+ neurons in the substantia nigra metabolically contributes to neurodegenerative phenotypeNARA Subscribed
Human Genetics · 2021 · Vol. 140 · Issue 10 · Springer
Shaul Lerner; Raya Eilam; Lital Adler; Julien Baruteau; Topaz Kreiser; Michael Tsoory; Alexander Brandis; Tevie Mehlman; Mina Ryten; Juan A. Botia; Sonia Garcia Ruiz; Alejandro Cisterna Garcia; Carlo Dionisi-Vici; Giusy Ranucci; Marco Spada; Ram Mazkereth; Robert McCarter; Rima Izem; Thomas J. Balmat; Rachel Richesson; Matthias R. Baumgartner; Jirair K. Bedoyan; Gerard Berry; Susan A. Berry; Peter Burgard; Lindsay Burrage; Curtis Coughlin; George A. Diaz; Gregory Enns; Renata C. Gallagher; Andrea Gropman; Cary O. Harding; Georg Hoffmann; Cynthia Le Mons; Shawn E. McCandless; J. Lawrence Merritt; Sandesh C. S. Nagamani; Andreas Schulze; Jennifer Seminara; Tamar Stricker; Mendel Tuchman; Susan Waisbren; James D. Weisfeld-Adams; Derek Wong; Marc Yudkoff; Ehud Gazit; Sandesh C. S. Nagamani; Ayelet Erez
Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expressed in dopaminergic neurons in the substantia nigra pars compacta, including the ALDH1A1 + subpopulation that is pivotal for the pathogenesis of Parkinson disease (PD). Neuronal l...
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