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Investigating Dynamic Interactions in Multivariate Climate Time Series: Insights From Transfer Entropy Analysis PerspectiveNARA Subscribed
Understanding how surface climate variables interact directionally remains challenging, particularly in complex terrain environments where nonlinear dynamics, terrain heterogeneity, and seasonal regime shifts limit the applicability of conventional correlation‐based analyses. This study develops a multivariate, cross‐station Transfer Entropy (TE) framework to diagnose directional climate interactions among wind speed, temperat...
β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer CellsNARA Subscribed
Purpose This study aimed to investigate the radiosensitizing potential of β-caryophyllene (BCP), a natural CB2 receptor agonist, in colorectal cancer (CRC) cells and to elucidate the underlying molecular mechanisms. Methods Murine CT26 and human HCT116 CRC cells were treated with BCP alone or in combination with radiotherapy (RT). Cell viability was evaluated using the MTT assay, and combination index (CI) values were calculat...
Dissolving microneedles incorporating kopexil multicomponent crystals for improved transdermal deliveryNARA Subscribed
Notwithstanding the rapid advancements in microneedle research, the applications of multicomponent crystals (MCCs) within microneedle drug delivery landscape remain largely underexplored. This study aimed at integrating crystal engineering with powder-carrying microneedle technology to overcome the current therapeutic obstacles in androgenetic alopecia (AGA). Kopexil (KPX), a minoxidil analog for AGA treatment, was successfull...