Megalocytivirus, a large double‐stranded DNA virus belonging to the Iridoviridae family, has infected over 100 species of fish, leading to significant economic losses in the aquaculture, food, and ornamental fish industries. These viruses exhibit icosahedral symmetry and have diameters ranging from 120 to 200 nm. Two distinct viral species of genus Megalocytivirus have been identified: Megalocytivirus pagrus 1 and Megalocytivi...