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SRS143 a semi-synthetic analogue of andrographolide against house dust mite induced allergic asthmaNARA Subscribed
Allergic asthma is one of the common forms of asthma. Upon exposure to allergens, mast cells actively release histamine into the airway, forcing the smooth muscles in the airway to undergo contraction, hence asthmatic attack. The therapeutics of asthma is commonly based on the use of steroids and topical bronchodilators. Steroid-resistant asthma has been on the rise and can be further exacerbated by any respiratory infection....
Uncovering the magnitude of African pangolin poaching with extensive nanopore DNA genotyping of seized scalesNARA Subscribed
Trade in pangolins is illegal, and yet tons of their scales and products are seized at various ports. These large seizures are challenging to process and comprehensively genotype for upstream provenance tracing and species identification for prosecution. We implemented a scalable DNA barcoding pipeline in which rapid DNA extraction and MinION sequencing were used to genotype a substantial proportion of pangolin scales subsampl...
Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assayNARA Subscribed
Modern drug development increasingly requires comprehensive models that can be utilized in the earliest stages of compound and target discovery. Here we report a phenotypic screening exercise in a high-throughput Organ-on-a-Chip setup. We assessed the inhibitory effect of 1537 protein kinase inhibitors in an angiogenesis assay. Over 4000 micro-vessels were grown under perfusion flow in microfluidic chips, exposed to a cocktail...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...