Healing failure in chronic wounds reflects a self-reinforcing pathology of unresolved inflammation, oxidative damage, poor angiogenesis, and disordered matrix turnover, compounded by a wound bed that turns abnormally alkaline. Apigenin, a plant-derived flavonoid, counters several of these processes through antioxidant and anti-inflammatory activity, but its low aqueous solubility and weak bioavailability make topical use ineff...

Objectives Epidermolysis Bullosa (EB) is a rare genetic disorder characterised by extreme skin fragility, chronic wounds, and high morbidity. Current management is largely supportive, highlighting an urgent need for innovative therapeutic strategies. This review synthesises recent advances in topical therapies, including wound dressings, tissue-engineered skin, and molecular therapies, and evaluates the potential of these appr...

The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthology plays a crucial role in understanding evolutionary patterns of genes and their functions. At the last Quest for Orthologs meeting (Montréal, Canada—2024), we discussed recent advances in orthology inference, with a focus on th...