Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activation of the MAPK signaling pathway decreases the levels of tumor-infiltrating lymphocytes in triple-negative breast cancer (TNBC) and is associated with worse survival. Here, we investigated...

Edwardsiella anguillarum causes Edwardsiellosis in fish, resulting in severe internal organ lesions and substantial economic losses in aquaculture. The limited efficacy of antibiotics in treating this disease, coupled with concerns regarding resistance and side effects, has driven interest in exploring fish vaccines. Various vaccine candidates derived from E. anguillarum, including inactivated cells and protein subunits, have...