Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activation of the MAPK signaling pathway decreases the levels of tumor-infiltrating lymphocytes in triple-negative breast cancer (TNBC) and is associated with worse survival. Here, we investigated...

Autism spectrum disorder (ASD), a neurodevelopmental disorder, is characterized by synaptic dysregulation as its underlying pathophysiological mechanism. AMP-activated protein kinase (AMPK), an intracellular energy sensor, plays a pivotal role in regulating synaptic integrity and function. Current treatments for ASD exhibit limited benefits in alleviating the core symptoms of ASD. Consequently, we investigated the therapeutic...

Introduction The myodural bridge (MDB) is considered one of the circulatory dynamics of cerebrospinal fluid (CSF). Initially identified in the human neck, it has since been documented across diverse vertebrates, including fish with analogous “MDB-like” structures. The teleost Takifugu rubripes , which exhibits a high degree of genetic homology with humans, serves as an excellent model for such comparative studies. Investigatin...

The African big-headed ant, Pheidole megacephala , is one of the most destructive invasive ant species, posing a significant threat to native biodiversity and ecosystem function, particularly in island ecosystems. Despite recent efforts to characterize pathogens in other major invasive ants, P . megacephala has received comparatively little attention. In this study, we characterized five novel RNA viruses actively replicating...