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Journal: Angiogenesis ×Author: Ching Lin ×Clear All Filters
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Angiogenesis · 2024 · Vol. 27 · Issue 3 · Springer
Aging is a natural process associated with chronic inflammation in the development of vascular dysfunction. We hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals. CCL4 inhibition reduced generation of reactive oxygen species (ROS), attenuated inflammation, and restored cell functions in e...