Autism spectrum disorder (ASD), a neurodevelopmental disorder, is characterized by synaptic dysregulation as its underlying pathophysiological mechanism. AMP-activated protein kinase (AMPK), an intracellular energy sensor, plays a pivotal role in regulating synaptic integrity and function. Current treatments for ASD exhibit limited benefits in alleviating the core symptoms of ASD. Consequently, we investigated the therapeutic...

Background Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae . However, the clinical efficacy of CPZ/SUL for the treatment of K. pneumoniae bacteremia has not been studied. Objectives This study aimed to associate the clinical outcomes of patients with bacteremia with the minimal i...

When the own ship encounters target ships in a close-quarter situation, an officer on watch needs to safely and timely alter the course of the vessel to avoid a collision. If ECDIS can automatically collect the navigation parameters and plot areas of collision as quasi-static obstruction areas, it will be much easier for seafarers to implement effective route planning. Hence, this study focuses on developing the MCARP model as...