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The kidney is a major regulator of phosphate metabolism. The body can lower systemic phosphate levels by increasing renal phosphate excretion, and kidney injury results in elevated serum phosphate concentrations (hyperphosphatemia). Chronic kidney disease (CKD) is associated with various organ injuries, including vascular calcification and cardiovascular disease, where hyperphosphatemia acts as a pathologic driver. Here we dis...
Clarifying species boundaries in oak powdery mildews: description of Erysiphe quercus-palustris sp. nov. and notes on E. abbreviataNARA Subscribed
Powdery mildews ( Erysiphaceae ) are obligate fungal pathogens that infect over 10,000 plant taxa worldwide. Oaks ( Quercus spp.) are a particularly important group of hosts due to their ecological and economic value. Recent molecular work has revealed that species infecting North American oaks are more diverse and host-specific than previously recognized. Here, we describe Erysiphe quercus-palustris sp. nov., collected on Que...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biologyNARA Subscribed
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers in ecology and evolution are co...
Motivation Terrestrial predators play key roles in cycling nutrients, as well as limiting prey populations, and shaping the behaviour of their prey. Prehistoric, historic and ongoing declines of the world's predators have reshaped terrestrial ecosystems and are a topic of conservation concern. However, the availability of ecologically relevant predator functional traits is limited, hampering efforts to understand macroecologic...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Machine Learning–Based Identification of Target Groups for Thrombectomy in Acute StrokeNARA Subscribed
Whether endovascular thrombectomy (EVT) improves functional outcome in patients with large-vessel occlusion (LVO) stroke that do not comply with inclusion criteria of randomized controlled trials (RCTs) but that are considered for EVT in clinical practice is uncertain. We aimed to systematically identify patients with LVO stroke underrepresented in RCTs who might benefit from EVT. Following the premises that (i) patients witho...
Our paper showcases the potential gain in scientific insights about blue carbon stocks (or total organic carbon) when additional rigor, in the form of a spatial autocorrelation component, is formally incorporated into the statistical model for assessing the variability in carbon stocks. Organic carbon stored in marsh soils, or blue carbon (BC), is important for sequestering carbon from the atmosphere. The potential for marshes...
Alkalinity export to the ocean is a major carbon sequestration mechanism in a macrotidal saltmarshNARA Subscribed
Saltmarshes are a blue carbon ecosystem accumulating large quantities of organic carbon in sediments. Some of this carbon can be transformed into dissolved inorganic carbon (DIC) and methane (CH 4 ) that may eventually be exported to the ocean or atmosphere. Although extensive studies have quantified specific components of the carbon budget such as carbon burial, limited attention has been given to pore‐water‐derived carbon an...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
The mangrove CO 2 pump: Tidally driven pore‐water exchangeNARA Subscribed
Atmospheric carbon dioxide (CO 2 ) is fixed by mangrove vegetation and stored in its biomass and sediments. Part of the sediment carbon can be exported to coastal waters via tidally driven pore‐water exchange. Here, we quantify pore water‐derived dissolved CO 2 export using in situ, high‐resolution observations of 222 Rn and CO 2 over a spring‐neap tidal cycle in a mangrove‐fringed estuary (Coffs Creek, Australia). 222 Rn‐deri...
Coastal carbon cycle changes following mangrove lossNARA Subscribed
Global mangrove loss is occurring from deforestation and extreme climatic events, but changes to the coastal carbon cycle following mangrove mortality and/or loss are not well understood. In 2015/2016, a massive climate‐driven mangrove dieback event occurred over ~ 1000 km of Australian coastline. To assess carbon loss following mortality, carbon fluxes in adjacent living and dead forest areas were compared 8 and 20 months pos...
Ice storms, defined by the US National Weather Service as freezing rain accumulations over 0.635 cm (0.25 inch), are often costly and destructive. Formation processes include the classic ‘melting’ process and supercooled warm rain process. Freezing rain is most commonly found ahead of a warm front or occlusion, where warm air is lifted over a cold shallow layer near the surface. Other synoptic patterns conducive to freezing ra...