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NARA Subscribed1
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Springer Nature1
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GeroScience1
Publication Year
20221
Christopher A. Foote results 1 · Newest (Page 1/1, per page 25)
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SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged miceNARA Subscribed
GeroScience · 2022 · Vol. 44 · Issue 3 · Springer
Rogerio N. Soares; Francisco I. Ramirez-Perez; Francisco J. Cabral-Amador; Mariana Morales-Quinones; Christopher A. Foote; Thaysa Ghiarone; Neekun Sharma; Gavin Power; James A. Smith; R. Scott Rector; Luis A. Martinez-Lemus; Jaume Padilla; Camila Manrique-Acevedo
Aging of the vasculature is characterized by endothelial dysfunction and arterial stiffening, two key events in the pathogenesis of cardiovascular disease (CVD). Treatment with sodium glucose transporter 2 (SGLT2) inhibitors is now known to decrease cardiovascular morbidity and mortality in type 2 diabetes. However, whether SGLT2 inhibition attenuates vascular aging is unknown. We first confirmed in a cohort of adult subjects...
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