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Springer Nature1
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Biotechnology Letters1
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20211
Christopher C. Frye results 1 · Newest (Page 1/1, per page 25)
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Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion proteinNARA Subscribed
Biotechnology Letters · 2021 · Vol. 43 · Issue 8 · Springer
Laura Bryan; Michael Henry; Niall Barron; Clair Gallagher; Ronan M. Kelly; Christopher C. Frye; Matthew D. Osborne; Martin Clynes; Paula Meleady
Objectives We used miRNA and proteomic profiling to understand intracellular pathways that contribute to high and low specific productivity (Qp) phenotypes in CHO clonally derived cell lines (CDCLs) from the same cell line generation project. Results Differentially expressed (DE) miRNAs were identified which are predicted to target several proteins associated with protein folding. MiR-200a was found to have a number of predict...
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