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Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseasesNARA Subscribed
To study the impact of necroptosis-induced chronic inflammation on age-related diseases and aging, two knockin mouse models ( Ripk3 -KI and Mlkl -KI) were generated that overexpress two genes involved in necroptosis ( Ripk3 or Mlkl ) when crossed to Cre transgenic mice. Crossing Ripk3 -KI or Mlkl -KI mice to albumin-Cre transgenic mice produced hepatocyte specific hRipk3 -KI or hMlkl -KI mice, which express the two transgenes...
Chow diet in mouse aging studies: nothing regular about itNARA Subscribed
Chow diet is used in the majority of rodent studies and, although assumed to be standardized for dietary source and nutritional contents, it varies widely across commercial formulations. Similarly, current approaches to study aging in rodents involve a single-diet formulation across the lifespan and overlook age-specific nutritional requirements, which may have long-term effects on aging processes. Together, these nutrition-ba...
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