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This systematic review examines the prevalence, underlying mechanisms, cohort characteristics, evaluation criteria, and cohort types in white matter hyperintensity (WMH) pipeline and implementation literature spanning the last two decades. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we categorized WMH segmentation tools based on their methodologies from January 1, 2000, to...
Natural hazards often occur in combination with other natural hazards rather than as isolated events. While some combinations of hazards are well studied and their physical connection is increasingly understood, other combinations have received considerably less attention. High temperatures are known to be an important component for conditions that lead to heavy rainfall; however, sequences of heatwaves followed by heavy rainf...
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states dur...
Weekly to multi‐month persistence in sets of daily weather patterns over Europe and the North Atlantic OceanNARA Subscribed
Persistence in time series of daily weather pattern (WP) classifications can provide useful information such as on the memory of broad‐scale atmospheric circulation. Despite this, research of WP persistence has lagged behind that exploring their frequencies of occurrence. We develop two methods for identifying persistence in a 167‐year time series of WPs defined over the North Atlantic–European domain. The first is an empirica...
Weather‐pattern, or weather‐type, classifications are a valuable tool in many applications as they characterize the broad‐scale atmospheric circulation over a given region. This study analyses the aspects of regional UK precipitation and meteorological drought climatology with respect to a new set of objectively defined weather patterns. These new patterns are currently being used by the Met Office in several probabilistic for...
Objective classification of extreme rainfall regions for the UK and updated estimates of trends in regional extreme rainfallNARA Subscribed
Extreme rainfall events pose considerable threats to society and critical infrastructure yet, by definitions, these events are rare. Reliable estimates of the likelihood of such events are required to assist with impact quantification and risk management. Regional frequency analysis of pooled extreme rainfall to estimate the likely impacts of a changing climate is a well established method to assess the probability of these ex...
An assessment of changes in seasonal and annual extreme rainfall in the UK between 1961 and 2009NARA Subscribed
There is a growing body of evidence supporting the Intergovernmental Panel on Climate Change's contestation that changes to hydrological extremes as a result of anthropogenic climate change are likely. There is also a growing level of concern among water resource managers about the nature of these changes and how we might adapt our behaviour to accommodate them. In particular, extreme multi‐day rainfall events have been a sign...
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