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Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson LaboratoryNARA Subscribed
The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer’s Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research...
Carbon source and weather in coastal North CarolinaNARA Subscribed
The increasing frequency of extreme weather events, including tropical cyclones, is altering the delivery and quality of organic matter (OM) exported from landscapes to estuaries. However, the mechanisms regulating these shifts, especially during multi‐year climatic oscillations, remain poorly understood. We used a new fluorescence–based mixing model to estimate dissolved OM (DOM) sources to the Neuse River Estuary, during a d...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
96-h methamphetamine self-administration elicits striatal dopamine depletion in male and female rats: a model of binge-like useNARA Subscribed
Background Methamphetamine is a psychostimulant with significant public health implications. Chronic methamphetamine use is linked to profound dysregulation of the dopaminergic system, cognitive deficits, and psychiatric symptoms. While traditional experimenter administered “binge” dosing models reliably produce dopaminergic neurotoxicity, they fail to capture the volitional, drug intake characteristic of human methamphetamine...
Experimental Immigration Mediates Ecological Selection and Drift in Monarch Microbiome AssemblyNARA Subscribed
The distribution of biodiversity depends on processes operating across scales, yet multiscale paradigms have struggled to permeate host‐microbiome research. Instead, host‐microbiome research has focused on host selection and has struggled to explain the high variation in microbial composition across individuals. By integrating multi‐scale ecological theory with experimental manipulation of bacteria colonizing monarch butterfly...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Positive Feedback on Climate Warming by Stream Microbial Decomposers Indicated by a Global Space‐For‐Time Substitution StudyNARA Subscribed
Decomposition of plant litter is a key ecological process in streams, whose contribution to the global carbon cycle is large relative to their extent on Earth. We examined the mechanisms underlying the temperature sensitivity (TS) of instream decomposition and forecast effects of climate warming on this process. Comparing data from 41 globally distributed sites, we assessed the TS of microbial and total decomposition using lit...
Mortality in a cohort of WTC-exposed law-enforcement officers compared to non-WTC law-enforcement officersNARA Subscribed
Purpose World Trade Center (WTC) rescue/recovery workers were exposed to materials hazardous to health. Previous studies found lower than expected mortality among WTC rescue/recovery workers when compared to general populations, possibly due to healthy worker effects, better healthcare access and/or incomparability of the groups. We compared mortality rates in WTC-exposed law enforcement officers (LEOs) with rates in LEOs empl...
Citizen science yields increased scientific capacity in exchange for science literacy and promises of a more responsive science to society’s needs. Yet, citizen science projects are criticized for producing few scientific outputs and having exploitative relationships with the citizens who participate. In the eagerness to capture new data, scientists can fail to see the value of citizen scientists’ expertise beyond data generat...
The extracellular release of dissolved organic carbon (DOC) from marine macroalgae supports coastal ecosystem function by supplying photosynthetically fixed carbon to higher trophic levels via the microbial loop. Despite its widely acknowledged biogeochemical importance, DOC is not typically included in primary production estimates of coastal systems. Additionally, little is known about how changes in species composition and c...
Coastal systems often depend on foundation species such as seagrasses that are supported by self-facilitation. Seagrass meadows, however, are threatened worldwide due to climate change and local human impact, disrupting self-facilitation leading to system instability. Florida Bay is a large seagrass dominated coastal ecosystem that suffered from multiple seagrass mortality events over the last half century driven by hypoxia, h...
Epiphytic microalgae are important contributors to the carbon and nutrient cycles yet are often overlooked during ecological surveys. In reef habitats, epiphytes are often found living on host organisms, including seaweeds or corals, and can influence community composition of higher trophic level taxa. Hence, understanding how epiphytes respond to different reef substrate materials can help inform designs of substrates intenti...