Christopher J. Merchant results 16
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Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesisNARA Subscribed
Chronic inorganic arsenic (iAs) exposure affects > 220 million people worldwide and skin cancer is a hallmark of long-term iAs exposure. Limited information exists regarding arsenic methylation by human keratinocytes and how methylation influences skin carcinogenesis. Inorganic arsenite (iAs III ) and its methylated metabolites disrupt diverse zinc finger proteins, leading to differential toxicity patterns. We examined arsenic...
Stability Specifications for Climate Data Records: Their Meaning and Application in Evaluating Geophysical Trend UncertaintyNARA Subscribed
When quantifying changes over time in the natural environment, the stability of the observations used should be considered. Stability conceptually refers to how accurately true geophysical changes and trends are reflected in observational data. We argue the need for a better approach to defining and quantifying stability consistently across climate data records. We propose that the appropriate stability metric is the stability...
The ENIGMA sports injury working group:– an international collaboration to further our understanding of sport-related brain injuryNARA Subscribed
Sport-related brain injury is very common, and the potential long-term effects include a wide range of neurological and psychiatric symptoms, and potentially neurodegeneration. Around the globe, researchers are conducting neuroimaging studies on primarily homogenous samples of athletes. However, neuroimaging studies are expensive and time consuming, and thus current findings from studies of sport-related brain injury are often...
To support calibration and validation of satellite sea surface temperature (SST) retrievals, over 60 high-resolution SST (HRSST) drifting buoys were deployed at sea between 2012 and 2017. Their data record is reviewed here. It is confirmed that sea state and immersion depth play an important role in understanding the data collected by such buoys and that the SST sensors need adequate insulation. In addition, calibration verifi...
Geographic and temporal variations in turbulent heat loss from lakes: A global analysis across 45 lakesNARA Subscribed
Heat fluxes at the lake surface play an integral part in determining the energy budget and thermal structure in lakes, including regulating how lakes respond to climate change. We explore patterns in turbulent heat fluxes, which vary across temporal and spatial scales, using in situ high‐frequency monitoring data from 45 globally distributed lakes. Our analysis demonstrates that some of the lakes studied follow a marked season...
Recent multivariate changes in the North Atlantic climate system, with a focus on 2005–2016NARA Subscribed
Major changes are occurring across the North Atlantic climate system, including in the atmosphere, ocean and cryosphere, and many observed changes are unprecedented in instrumental records. As the changes in the North Atlantic directly affect the climate and air quality of the surrounding continents, it is important to fully understand how and why the changes are taking place, not least to predict how the region will change in...
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