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Mitragynine reduces methamphetamine self-administration in rats without disrupting food-maintained respondingNARA Subscribed
Rationale Kratom ( Mitragyna speciosa ), a plant native to Southeast Asia, has become popular in the United States for its reported ability to treat substance use disorders (SUD). Mitragynine (MG) is the most abundant alkaloid found in kratom. Objectives The present studies evaluated whether MG decreases methamphetamine self-administration under both fixed-ratio (FR) and progressive-ratio (PR) schedules. In a separate cohort w...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Sustained observation is key to measuring physical and ecological variability in the Northwest Atlantic. Here we illustrate how a partnership with a merchant marine container vessel in service between New Jersey and Bermuda twice per week gives scientists a unique window into upper ocean currents, water properties, and marine ecology. Scientific observations collected from CMV Oleander, operated by Bermuda Container Line/Neptu...
An experimental study of wet-cooking in organic vessels: implications for understanding the evolution of cooking technologiesNARA Subscribed
The ability to control and direct fire is a major evolutionary step in the human story. The development of aceramic cooking technologies is less well understood as they rarely survive in the archaeological record. However, inferential evidence such as fire-cracked rocks, earthen pits and heated bones suggest a variety of cooking methods were used prior to the invention of ceramics. Yet there is a paucity of experimental eviden...
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) geneNARA Subscribed
Otosclerosis is a bone disorder of the otic capsule and common form of late-onset hearing impairment. Considered a complex disease, little is known about its pathogenesis. Over the past 20 years, ten autosomal dominant loci ( OTSC1-10 ) have been mapped but no genes identified. Herein, we map a new OTSC locus to a 9.96 Mb region within the FOX gene cluster on 16q24.1 and identify a 15 bp coding deletion in Forkhead Box L1 co-s...
Multiple tracers demonstrate distinct sources of dissolved organic matter to lakes of the Mackenzie Delta, western Canadian ArcticNARA Subscribed
Lakes of the Mackenzie Delta occur across a gradient that contains three clear end members: those that remain connected to river‐water channels throughout the summer; those that receive only brief inputs of river water during an annual spring flood but contain dense macrophyte stands; and those that experience significant permafrost thaw along their margins. We measured dissolved organic carbon (DOC) concentration, dissolved o...
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