Rationale Cannabis use continues to increase globally, with a growing proportion of users exhibiting problematic patterns of use. Although neural differences in reward and inhibitory control systems are commonly reported in individuals who use cannabis relative to individuals not reporting cannabis use, findings using behavioural tasks are inconsistent. This is possibly due to lack of differentiation between regular and more p...

Calorie restriction has been shown to dramatically extend lifespan in a range of species. Beyond longevity, calorie restriction is also reported to improve cognitive function, ameliorate neurodegeneration and peripheral nerve damage, reduce cancer incidence, and is commonly used to increase motivation in studies of behaviour. The mouse has been the most common species for these experiments and whilst efforts are ongoing to dem...