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Mite domatia — small structures on plant leaves that house mutualistic mites — are widespread across plants yet remain relatively understudied. Here we investigate the chemistry and micromorphology of mite domatia across sympatric species of broadleaf deciduous woody species that have convergently evolved tuft-form mite domatia. Specifically, we test whether domatia display similar micromorphological and chemical properties us...
Parkinson’s disease dementia and hearing impairment, are they related? A UK biobank pilot analysisNARA Subscribed
Hearing impairment is implicated as a risk factor for the incidence of all-cause dementia. However, few studies have explored the relationship between hearing loss and specific rarer dementia subtypes. Therefore, this pilot study sought to explore whether hearing impairment, estimated using a speech-in-noise test (the digit triplet test, DTT), is a risk factor for Parkinson’s disease dementia (PDD) incidence. We conducted a pr...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Which Plant Traits Increase Soil Carbon Sequestration? Empirical Evidence From a Long‐Term Poplar Genetic Diversity TrialNARA Subscribed
Plants play a key role in mediating soil response to global change, and breeding or engineering crops to increase soil organic carbon (SOC) storage is a potential route to land‐based carbon dioxide removal in agricultural systems. However, due to limited observational datasets plus shifting paradigms of SOC stabilization, it is unclear which plant traits are most important for enhancing different types of soil organic matter....
Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decadeNARA Subscribed
Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioeconomic status (SES) and decrements in kidney function across a decade. Biomarker data were from 252 non-Hispanic (NH) Black and white participants who had consented to genetic analyses in Wav...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Bridging the gap: exploring consumer knowledge, perceptions, and willingness to pay for aquaponics products across the UKNARA Subscribed
Aquaponics (a sub-field of integrated agri-aquacultural practices (IAAS)) has emerged as a novel approach to combat global food security, reduce soil erosion and nutrient loss, and mitigate agronomic greenhouse gas (GHG) emissions. However, little remains known of potential consumer markets. Despite recent research throughout Europe, Central America, Australia, and the Middle East, this work represents the first large-scale ev...
Coefficients in Taylor's law increase with the time scale of water clarity measurements in a global suite of lakesNARA Subscribed
Identifying the scaling rules describing ecological patterns across time and space is a central challenge in ecology. Taylor's law of fluctuation scaling, which states that the variance of a population's size or density is proportional to a positive power of the mean size or density, has been widely observed in population dynamics and characterizes variability in multiple scientific domains. However, it is unclear if this phen...
A sequence of weather‐driven hydrodynamic events stimulates the formation of harmful algal blooms on an oligotrophic lakeNARA Subscribed
Harmful algal blooms (HABs) are common in many eutrophic lakes and frequently associated with nutrient excesses, warm waters, and calm conditions. While HABs can also occur in oligotrophic waterbodies, bloom‐stimulating factors remain elusive for these ecosystems. Here, using a high‐frequency sensor platform supported by hydrodynamic modeling, we document a clearly linked sequence of three hydrodynamic events that immediately...