Christopher Watson results 66
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Introduction Toxicologists may use high dose n-acetylcysteine (HD-NAC) for early-treated high-risk acetaminophen ingestions (EHRAI) given concerns over standard NAC (S-NAC) dosing’s efficacy. We utilize the novel, clinically relevant outcome of mean additional 16-hour NAC maintenance infusions (NMI) to evaluate differences in treatment duration for EHRAI patients treated with S-NAC versus HD-NAC. Methods Retrospective multista...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
Positive Feedback on Climate Warming by Stream Microbial Decomposers Indicated by a Global Space‐For‐Time Substitution StudyNARA Subscribed
Decomposition of plant litter is a key ecological process in streams, whose contribution to the global carbon cycle is large relative to their extent on Earth. We examined the mechanisms underlying the temperature sensitivity (TS) of instream decomposition and forecast effects of climate warming on this process. Comparing data from 41 globally distributed sites, we assessed the TS of microbial and total decomposition using lit...
A sequence of weather‐driven hydrodynamic events stimulates the formation of harmful algal blooms on an oligotrophic lakeNARA Subscribed
Harmful algal blooms (HABs) are common in many eutrophic lakes and frequently associated with nutrient excesses, warm waters, and calm conditions. While HABs can also occur in oligotrophic waterbodies, bloom‐stimulating factors remain elusive for these ecosystems. Here, using a high‐frequency sensor platform supported by hydrodynamic modeling, we document a clearly linked sequence of three hydrodynamic events that immediately...
Co-Production of Knowledge at Sumida Farm Trains a New Generation of Community-Engaged ScientistsOA Marine
The Sumida watercress farm near Pu‘uloa (Pearl Harbor), O‘ahu has been in continuous operation since 1928. This family-run farm (Figure 1a) produces 70% of the state’s watercress crop, making it critical to Hawai‘i’s food production. The farm’s watercress relies completely on water from freshwater springs. However, the amount of water flowing from the springs has declined by half over the last century as a result of groundwate...
Isopropyl alcohol inhalation versus 5-HT3 antagonists for treatment of nausea: a meta-analysis of randomised controlled trialsNARA Subscribed
Purpose Nausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT 3 ) antagonists are often ineffective, while also conferring a risk of potential adverse events. Isopropyl alcohol (IPA) has been proposed as a treatment for nausea. We aimed to compare IPA with 5-HT 3 antagonists for the treatment of nausea across all clinical settings. Methods MEDLINE, EMBASE, PubMed, CENTRAL and CINAHL we...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Comparison of state-of-the-art GNSS-observed and predicted ocean tide loading displacements across AustraliaNARA Subscribed
We seek to quantify and understand the residual signal in GPS and GLONASS estimates of ocean tide loading displacements (OTLDs) after removing state-of-the-art model estimates. To consider contributions over a broad spatial scale, we estimate OTLD over the Australian continent using $$\sim $$ ∼ 5.5 years of continuous GPS and GLONASS data from 360 sites. We compare these with modelled estimates, with a focus on the lunar semid...
Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolutionNARA Subscribed
Following prolonged cell division, mesenchymal stem cells enter replicative senescence, a state of permanent cell cycle arrest that constrains the use of this cell type in regenerative medicine applications and that in vivo substantially contributes to organismal ageing. Multiple cellular processes such as telomere dysfunction, DNA damage and oncogene activation are implicated in promoting replicative senescence, but whether m...