Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activation of the MAPK signaling pathway decreases the levels of tumor-infiltrating lymphocytes in triple-negative breast cancer (TNBC) and is associated with worse survival. Here, we investigated...

The brain supports consciousness through regional heterogeneity. However, the spatial complexity of its metabolome under anesthesia remains unclear. In this study, we established a spatial metabolomic atlas of the mouse brain under wakefulness, inhalation anesthesia, and injectable anesthesia. In total, 727 metabolites were identified and spatially mapped across 11 representative brain regions. We found that anesthesia signifi...