Claudia Stephan results 48
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Pathogens in the garden dormouse Eliomys quercinusNARA Subscribed
Wild rodents are important reservoirs and vectors of various pathogens, and play a crucial role in the spread of zoonotic pathogens. The garden dormouse ( Eliomys quercinus ), an arboreal nocturnal rodent species native to Europe, has declined throughout much of its natural range in recent decades. The reason for this ongoing decline is not yet fully understood, but infectious diseases may play a role. This study aimed to revi...
Social learning has been shown to considerably facilitate the acquisition of information and has been as such typically studied in animals living in complex social groups. Comparably little is known about social learning in less gregarious species, notably when heterospecific demonstrators are used. Here, we investigated the capacity for social learning in two captive Harpy Eagles (Harpia harpyja) , a solitary raptor species c...
Increased vascularization of the subchondral region in human osteoarthritic femoral head in the elderlyNARA Subscribed
This study aimed to quantitatively analyze subchondral vascularization during the progression of osteoarthritis (OA) in the elderly, particularly regarding the timing of initial blood vessel emergence and when their density peaks. A total of 129 independent areas from 43 human femoral heads, obtained through arthroplasty for OA or hemiarthroplasty for fractures, were analyzed. The femoral heads were grouped by Kellgren-Lawrenc...
The Treasury of Wharton's JellyNARA Subscribed
Background Postnatal umbilical cord tissue contains valuable mesenchymal progenitor cells of various differentiation stages. While mesenchymal stem cells are plastic-adherent and tend to differentiate into myofibroblastic phenotypes, some round cells detach, float above the adherent cells, and build up cell aggregates, or form spheroids spontaneously. Very small luminescent cells are always involved as single cells or within c...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Systemic mesalazine treatment prevents spontaneous skin fibrosis in PLK2-deficient miceNARA Subscribed
Skin fibrosis is a complex biological remodeling process occurring in disease like systemic sclerosis, morphea, or eosinophilic fasciitis. Since the knowledge about the underlying pathomechanisms is still incomplete, there is currently no therapy, which prevents or reverses skin fibrosis sufficiently. The present study investigates the role of polo-like kinase 2 (PLK2) and the pro-fibrotic cytokine osteopontin (OPN) in the pat...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...