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The relationships between flying Antarctic seabirds and their at-sea environments remain poorly understood, particularly outside of the breeding season. Improving our knowledge of how these marine predators use their habitat is a critical step towards conservation of these species. We tracked 27 adult Snow Petrels from two large breeding colonies in East Antarctica during the Austral winter (non-breeding period) – when they ar...
Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody AssayNARA Subscribed
Twenty percent of baseline patient samples exhibited a pre-existing response in a bridging anti-drug antibody (ADA) assay for a human IgG4 monoclonal antibody (mAb) therapeutic. In some cases, assay signals were more than 100-fold higher than background, potentially confounding detection of true treatment-emergent ADA responses. The pre-existing reactivity was mapped by competitive inhibition experiments using recombinant prot...
Cooperative breeding decreases the direct reproductive output of subordinate individuals, but cooperation can be evolutionarily favored when there are challenges or constraints to breeding independently. Environmental factors, including temperature, precipitation, latitude, high seasonality, and environmental harshness have been hypothesized to correlate with the presence of cooperative breeding. However, to test the relations...
Climate change and Southern Ocean ecosystems I: how changes in physical habitats directly affect marine biotaNARA Subscribed
Antarctic and Southern Ocean ( ASO ) marine ecosystems have been changing for at least the last 30 years, including in response to increasing ocean temperatures and changes in the extent and seasonality of sea ice; the magnitude and direction of these changes differ between regions around Antarctica that could see populations of the same species changing differently in different regions. This article reviews current and expect...
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