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GeroScience2
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20231
Colleen Pappas results 2 · Newest (Page 1/1, per page 25)
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Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adultsNARA Subscribed
GeroScience · 2025 · Vol. 47 · Issue 3 · Springer
Colleen Pappas; Christopher E. Bauer; Valentinos Zachariou; T. J. Libecap; Beatriz Rodolpho; Tiffany L. Sudduth; Peter T. Nelson; Gregory A. Jicha; Anika MS Hartz; Xingfeng Shao; Danny J. J. Wang; Brian T. Gold
There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) and developing biomarkers to identify at-risk individuals. A combination of biofluid and neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels of S100 calcium-binding protein B (S100B), which has been linked with blood–brain-barrier (BBB...
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Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal agingNARA Subscribed
GeroScience · 2023 · Vol. 46 · Issue 1 · Springer
Valentinos Zachariou; Colleen Pappas; Christopher E. Bauer; Xingfeng Shao; Peiying Liu; Hanzhang Lu; Danny J. J. Wang; Brian T. Gold
The blood–brain barrier (BBB) undergoes functional changes with aging which may contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI technique can measure the rate of water exchange across the BBB ( k w ) and may thus be sensitive to age-related alterations in water exchange at the BBB. However, studies investigating relationships between k w and cognition have reported different direct...
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