Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal and aggressive malignancies with a 5-year survival rate less than 9%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~ 18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. Alterations of miR expressions can...

A significant increase in treatment pace and scale is needed to restore dry western US forest resilience owing to increasingly frequent and severe wildfire and drought. We propose a pyrosilviculture approach to directly increase large-scale fire use and modify current thinning treatments to optimize future fire incorporation. Recommendations include leveraging wildfire’s “treatment” in areas burned at low and moderate severity...