Despite growing recognition that natural rewards can mitigate stress responses, the underlying neurobiological mechanisms remain poorly understood. Here, we examined whether limited sucrose intake (LSI), a paradigm of repeated natural food reward, induces structural plasticity in parvalbumin-expressing (PV+) interneurons and their perineuronal nets (PNNs) within the medial prefrontal cortex (mPFC), a key region involved in str...