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The 4E-BPs as Translational Regulators in Neurological Disorders: Molecular Mechanisms and Therapeutic PotentialNARA Subscribed
Protein translation is essential for maintaining the optimal functioning of the human nervous system. The 4E-Binding proteins (4E-BPs) are central regulators of this process, acting on the initiation factor eIF4E. Three homologs 4E-BP1, 4E-BP2, and 4E-BP3, are differentially expressed, with the phosphorylation state controlling cap-dependent translation in response to diverse physiological inputs, including growth factors, cyt...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Bridge to the future: Important lessons from 20 years of ecosystem observations made by the OzFlux networkNARA Subscribed
In 2020, the Australian and New Zealand flux research and monitoring network, OzFlux, celebrated its 20 th anniversary by reflecting on the lessons learned through two decades of ecosystem studies on global change biology. OzFlux is a network not only for ecosystem researchers, but also for those ‘next users’ of the knowledge, information and data that such networks provide. Here, we focus on eight lessons across topics of cli...
Testing a global standard for quantifying species recovery and assessing conservation impactNARA Subscribed
Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a “Green List of Species” (now the IUCN Green Status of Species). A draft Green Status framework for assessing species’ progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement aga...
Assessing the scope and severity of threats is necessary for evaluating impacts on populations to inform conservation planning. Quantitative threat assessment often requires monitoring programs that provide reliable data over relevant spatial and temporal scales, yet such programs can be difficult to justify until there is an apparent stressor. Leveraging efforts of wildlife management agencies to record winter counts of hiber...
Aim Forest carbon storage is the result of a multitude of interactions among biotic and abiotic factors. Our aim was to use an integrative approach to elucidate mechanistic relationships of carbon storage with biotic and abiotic factors in the natural forests of temperate Australia, a region that has been overlooked in global analyses of carbon‐biodiversity relations. Location South‐eastern Australia. Time period 2010–2015. Ma...
Quantifying species recovery and conservation success to develop an IUCN Green List of SpeciesNARA Subscribed
Stopping declines in biodiversity is critically important, but it is only a first step toward achieving more ambitious conservation goals. The absence of an objective and practical definition of species recovery that is applicable across taxonomic groups leads to inconsistent targets in recovery plans and frustrates reporting and maximization of conservation impact. We devised a framework for comprehensively assessing species...
Testing the generality of above‐ground biomass allometry across plant functional types at the continent scaleNARA Subscribed
Accurate ground‐based estimation of the carbon stored in terrestrial ecosystems is critical to quantifying the global carbon budget. Allometric models provide cost‐effective methods for biomass prediction. But do such models vary with ecoregion or plant functional type? We compiled 15 054 measurements of individual tree or shrub biomass from across Australia to examine the generality of allometric models for above‐ground bioma...
Does productivity drive diversity or vice versa? A test of the multivariate productivity–diversity hypothesis in streamsNARA Subscribed
The idea that productivity regulates species diversity is deeply ingrained in the field of ecology. Yet, over the past few decades, an increasing number of experiments have shown that species diversity controls, rather than simply responds to, biomass production. These contrasting perspectives have led to a seeming paradox: Is diversity the cause or the consequence of biological production? Here we present empirical evidence f...
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