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In El Bagre, Nechí, Zaragoza, and three other municipalities that comprise the Bajo Cauca region of Antioquia, an estimated total of 28.000 ha have been affected by illegal gold mining, where environmental liabilities such as mine tailings are distributed throughout the area. Urban areas, especially the main urban centers, may be exposed to environmental contaminants and their associated adverse effects. Studies that contribut...
Water pollution from agricultural, industrial, and urban activities threatens aquatic ecosystems and the essential services they provide. Excess nitrogen has been identified as a key driver of water quality degradation, impacting biodiversity, food security, and human health. One approach to mitigating nitrogen pollution is water quality offsetting, compensating for pollution impacts by implementing nitrogen reduction measures...
Despite their potential to inform sustainable regional harvest and climate‐resilient fisheries management, spatial stock assessment models remain underused for management advice. To identify barriers that inhibit broader use of these methods, we conducted a blinded international simulation experiment mimicking real‐world stock assessment development when confronting spatial complexity. Seven analyst teams built spatially aggre...
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel diseaseNARA Subscribed
The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function and therapeutic potential in inflammatory diseases. Although Treg-based immunotherapy offers promise for restoring immune tolerance, clinical application is limited by the instability and reduced potency of iTregs. STAT6 signaling has been implicated in destabilizing Foxp3 expression, a key marker of Treg ide...
Mesolimbic dopamine (DA) regulates activation and effort in motivated behaviors. Impairments in DA function induce motivational symptoms such as anergia and fatigue seen in depression. Stress modulates DA depending on its duration and intensity. Early-life events such as maternal separation (MS) could act as stressors, affecting brain development and leading to behavioral changes later in life. However, little is known about t...
Informatics for toxicokineticsNARA Subscribed
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
Positive Feedback on Climate Warming by Stream Microbial Decomposers Indicated by a Global Space‐For‐Time Substitution StudyNARA Subscribed
Decomposition of plant litter is a key ecological process in streams, whose contribution to the global carbon cycle is large relative to their extent on Earth. We examined the mechanisms underlying the temperature sensitivity (TS) of instream decomposition and forecast effects of climate warming on this process. Comparing data from 41 globally distributed sites, we assessed the TS of microbial and total decomposition using lit...
Populations must continuously respond to environmental change or risk extinction. These responses can be measured as phenotypic rates of change, which allow researchers to predict their contemporary evolutionary responses. In 1999, a database of phenotypic rates of change in wild populations was compiled. Since then, researchers have used (and expanded) this database to examine the phenotypic responses as a function of the fea...
Advances in high-throughput sequencing and bioinformatic data processing have prompted a transition in wildlife and fisheries genetics from the use of allozymes, mtDNA, or microsatellites towards markers that are more amenable to genotyping by sequencing, increasing the amount of data obtained for a lower cost with less time-consuming techniques. Microhaplotypes are novel multi-allelic genetic markers that utilize a high-throu...