Anadromous rainbow smelt ( Osmerus mordax , [Mitchill 1814]) are found along the northeast Atlantic coastline of North America, with their range now limited to north of Cape Cod, Massachusetts, USA. Although their anadromous life cycles are described broadly, gaps remain regarding how adult rainbow smelt use estuaries post‐spawning, including movement behaviors, habitats used, and specific timing of emigration to coastal water...

Ocean data synthesis products for specific biogeochemical essential ocean variables have the potential to facilitate today’s biogeochemical ocean data usage and comply with the Findable Accessible Interoperable and Reusable (FAIR) data principles. The products constitute key outputs from the Global Ocean Observation System, laying the observational foundation for information and services regarding climate and environmental sta...

Dungeness crab ( Metacarcinus magister ) have significant socioeconomic value, but are threatened by ocean acidification (OA) and other environmental stressors that are driven by climate change. Despite evidence that adult harvests are sensitive to the abundance of larval populations, relatively little is known about how Dungeness megalopae will respond to these stressors. Here we evaluate the ability to use micro-computed tom...

A cell-based assay was developed to detect neutralizing anti-drug antibodies (NAbs) against odronextamab, a CD20xCD3 bispecific monoclonal antibody (mAb) under investigation for treatment of CD20+ B cell malignancies. In this assay, odronextamab bridges between two cell types, CD20-expressing HEK293 cells and CD3-expressing Jurkat T cells that generate a luciferase signal upon CD3 clustering. Patient samples containing NAbs di...

Pathogenic variants in aminoacyl-tRNA synthetases (ARS1) cause a diverse spectrum of autosomal recessive disorders. Tyrosyl tRNA synthetase (TyrRS) is encoded by YARS1 ( cytosolic , OMIM*603,623 ) and is responsible of coupling tyrosine to its specific tRNA. Next to the enzymatic domain, TyrRS has two additional functional domains (N-Terminal TyrRS Mini and C-terminal EMAP-II-like domain) which confer cytokine-like functions....

Over the past decades, fractured and karst groundwater systems have been studied intensively due to their high vulnerability to nitrate (NO 3 − ) contamination, yet nitrogen (N) turnover processes within the recharge area are still poorly understood. This study investigated the role of the karstified recharge area in NO 3 − transfer and turnover by combining isotopic analysis of NO 3 − and nitrite (NO 2 − ) with time series da...

Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, the role of the most suitable host cell for EV enrichment and preclinical stroke treatment remains elusive. The present study aimed to evaluate the therapeutic potential of EVs derived from neural progenitor...