Intrinsic capacity (IC) is a key construct within the healthy ageing framework. However, the correlations among IC domains and their association with health outcomes in very old adults remain unclear. This study aimed to characterise the relationships among IC domains using network analysis and to examine their association with mortality in community-dwelling octogenarians from the Invecchiamento e Longevità nel Sirente (ilSIR...

Choices conservation organizations make when designing and implementing protected area strategies affect the timing of land protection. Well‐timed habitat protection will have a greater impact on biodiversity outcomes; yet, decisions affecting the timing of protection have received much less attention than other aspects of protected area design. We reviewed evidence on the timing of protected area establishment and on temporal...

Atmospheric CO 2 and temperature are rising concurrently, and may have profound impacts on the transcriptional, physiological and behavioural responses of aquatic organisms. Further, spring snowmelt may cause transient increases of p CO 2 in many freshwater systems. We examined the behavioural, physiological and transcriptomic responses of an ancient fish, the lake sturgeon ( Acipenser fulvescens ) to projected levels of warmi...

There is growing evidence that the composition of river microbial communities gradually transitions from terrestrial taxa in headwaters to unique planktonic and biofilm taxa downstream. Yet, little is known about fundamental controls on this community transition across scales in river networks. We hypothesized that community composition is controlled by flow‐weighted travel time of water, in combination with temperature and di...

Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated with Alzheimer’s disease and cardiovascular disease, the latter being the most common cause of mortality in people worldwide. In contrast, naturally occurring cancer represents the leading cause of death in pet dogs, and specific breeds like the Golden Retriever (GR) carry up to a 65% cancer-related death ra...

Episodic ataxia type 1 (EA1) is a rare autosomal potassium channelopathy, due to mutations in KCNA1 . Patients have childhood onset of intermittent attacks of ataxia, dizziness or imbalance. In order to quantify the natural history of EA1, its effect on quality of life and in preparation for future clinical trials, we set up an international multi-centre study of EA1. We recruited thirty-three participants with EA1: twenty-thr...

Nitrous oxide (N 2 O) evasion from streams and rivers is a significant, yet highly uncertain, flux in nitrogen cycle models. Most global estimates of lotic N 2 O emission assume that evasion rates are proportional to inorganic nitrogen inputs to a stream or river. However, many field studies do not detect relationships between lotic N 2 O evasion and dissolved nitrogen concentration, highlighting the need for better understand...