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Regulation of PDGF-BB signaling in placental pericytes by soluble PDGFRβ isoforms: implications for fetoplacental vascular developmentNARA Subscribed
Vascular remodeling within the developing fetus and placenta is essential for supporting the growth and function of emerging tissues and organs. Pericytes (PCs) play a central role in stabilizing and maturing microvascular networks by extending along endothelial cells (ECs) and reinforcing vessel integrity. In the placenta, as in other organs, PC–EC communication is mediated in part by platelet-derived growth factor-BB (PDGF‑B...
Divergence in migratory behaviour represents a striking and common axis of life‐history variation in animals. Plastic changes in adult animals in preparation for migration are well known, but the differences in early development between migratory and non‐migratory forms are not well documented. These differences might contribute to reproductive isolation because of the potentially substantial divergence in metabolism and physi...
Relationship of temperature with declines and persistence of Myotis lucifugus after white‐nose syndromeNARA Subscribed
White‐nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans (Pd), ranks among the most devastating wildlife diseases in recent history and is driving severe declines in North American bats. Identifying environmental factors that influence both the severity of population crashes and the potential for population persistence is essential for effective mitigation. We used a long‐term dataset from hibernacula acros...
Anthropogenic debris accumulation in the Argentine deep sea: evidence of an irreversible sinkOA Marine
The seafloor is recognized as a major sink for marine debris, while deep-sea litter remains poorly investigated due to the logistical and economic constraints associated with seabed exploration. This study reports for the first time the occurrence of marine debris found on the Argentine deep seafloor using the SOI’s Remotely Operated Vehicle (ROV), providing the first documented evidence for this region. A total of 29 litter i...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Soil fauna regulates litter decomposition and soil organic matter transformation, acting as both litter and microbial feeders. Whether these feeding modes shift along environmental gradients remains unclear. We tested if microbivory increases with decreasing litter quality and in colder climates, both factors limiting detritus digestion by fauna. Using stable isotope composition (δ 13 C, δ 15 N) of 7408 soil invertebrate sampl...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
S25-03 The use of natural language processing in toxicologyNARA Subscribed
Multispecies coral reef fisheries are typically managed by local communities who often lack research and monitoring capacity, which prevents estimation of well‐defined sustainable reference points to perform locally relevant fishery assessments. Recent research modeling coral reef fisheries globally has estimated multispecies sustainable reference points (i.e., the maximum reef fish yields that can be harvested sustainably and...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...