Gene-based therapies are being developed for retinal diseases, including RS1- related X-linked retinoschisis. Therefore it is essential to determine which variants are pathogenic and which are benign when enrolling patients. The Clinical Genome Resource (ClinGen) X-Linked Inherited Retinal Diseases (XLRD) Variant Curation Expert Panel (VCEP) brings together clinician scientists, molecular biologists, and geneticists to apply t...

The Spontaneously Hypertensive Rat (SHR) is a widely used model for hypertension and, more recently, for neuropsychiatric disorders such as ADHD and Substance Use Disorder (SUD). Despite a common origin, SHR substrains from different vendors exhibit distinct behavioral phenotypes, particularly in models of SUD. This study characterizes the genomic landscape of two such substrains, SHR/NCrl and SHR/NHsd, using high-fidelity lon...

Anthers are essential in plant reproduction and are also crucial in agriculture, because hybrid seed production typically relies on the manipulation of male fertility. Sorghum ( Sorghum bicolor L. Moench) is the fifth most produced grain crop in the world. However, relatively little is known about the genetic mechanisms that regulate anther development and male fertility in sorghum. Here, we report the morphological characteri...

Extreme climatic perturbations are becoming increasingly frequent, with substantial and long‐lasting legacy effects on biodiversity and ecosystems that may be compounded by human pressures such as illegal hunting. It is therefore vital to develop a better understanding of how best to manage and enhance ecosystem recovery. Using 15 years of data (2005–2019) from subtropical China, we investigated how an extreme ice storm event...