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Expert consensus on passive heating interventions to promote skeletal muscle strength and mass: a delphi studyNARA Subscribed
Purpose Passive heating has emerged as a potential non‑exercise method to support muscle strength and mass, but its application is limited by inconsistent protocols and unclear dosage and safety guidelines. This study used a Delphi methodology to establish expert consensus on key parameters for passive heating interventions targeting neuromuscular and muscle morphology outcomes. Methods An international panel of academic exper...
Understanding how temperature‐sensitive organisms respond to environmental change is central to addressing challenges in public health, biodiversity conservation and food security. For many ectotherms, abiotic and biotic factors shape their abundance and distribution by generating stage‐specific variation in life history traits. Although previous studies have examined temperature, rainfall, competition and habitat quality in r...
Introduction Picocyanobacteria from the genera Prochlorococcus and Synechococcus thrive across the globe in aquatic environments, have relatively small genomes, and have growth dynamics regulated by both viral interactions and abiotic conditions, making them excellent model organisms for exploring host-pathogencoevolution. Methods We developed and refined methods to sample and sequence cyanobacteria, cyanophages, and measured...
Prof Stephen P. Long, FRS (1950–2025)NARA Subscribed
Multiple Pleistocene refugia for Arctic Bell‐Heather revealed with genomic analyses of modern and historic plantsNARA Subscribed
Aim Arctic plants survived the Pleistocene glaciations in unglaciated refugia. The number, ages, and locations of these refugia are often unclear. We use high‐resolution genomic data from present‐day and Little‐Ice‐Age populations of Arctic Bell‐Heather to re‐evaluate the biogeography of this species and determine whether it had multiple independent refugia or a single refugium in Beringia. Location Circumpolar Arctic and Coas...
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. Our previous evaluation of FDA-approved drugs for their antileukemic activity...
Central versus peripheral mechanisms of cold-induced vasodilation: a study in the fingers and toes of people with paraplegiaNARA Subscribed
Purpose This study examined physiological and perceptual parameters related to cold-induced vasodilation (CIVD) in the fingers and toes of people with paraplegia and compared them with responses observed in able-bodied individuals. Methods Seven participants with paraplegia and seven able-bodied individuals participated in a randomized matched-controlled study involving left-hand and -foot immersion in cold water (8 ± 1 °C) fo...
Bringing the Nature Futures Framework to life: creating a set of illustrative narratives of nature futuresNARA Subscribed
To halt further destruction of the biosphere, most people and societies around the globe need to transform their relationships with nature. The internationally agreed vision under the Convention of Biological Diversity—Living in harmony with nature—is that “By 2050, biodiversity is valued, conserved, restored and wisely used, maintaining ecosystem services, sustaining a healthy planet and delivering benefits essential for all...
The seas of Southeast Asia are home to some of the world’s most diverse ecosystems and resources that support the livelihoods of millions of people. Climate change will bring temperature changes, acidification and other environmental change, with uncertain consequences for human and natural systems, but there has been little regional-scale climate modelling of the marine ecosystem. We present initial dynamically downscaled pro...
The Hong Kong oyster Magallana hongkongensis, previously known as Crassostrea hongkongensis, is a true oyster species native to the estuarine-coast of the Pearl River Delta in southern China. The species—with scientific, ecological, cultural, and nutritional importance—has been farmed for hundreds of years. However, there is only limited information on its genetics, stress adaptation mechanisms, and gut microbiota, restricting...
Mechanisms of breast cancer metastasisNARA Subscribed
Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and ot...
Sea Urchins Play an Increasingly Important Role for Coral Resilience Across Reefs in TaiwanOA Marine
Herbivores are an important functional group that control algae, create new space, and promote recruitment for coral recovery. However, on many coral reefs, overfishing has greatly decreased the density of herbivores, especially fishes and gastropods, impairing coral resilience. On such overfished reefs, remnant herbivores that are not target species of local fisheries, e.g., sea urchins, are expected to play an increasingly i...
Large‐scale and long‐term changes in fish abundance and distribution in response to climate change have been simulated using both statistical and process‐based models. However, national and regional fisheries management requires also shorter term projections on smaller spatial scales, and these need to be validated against fisheries data. A 26‐year time series of fish surveys with high spatial resolution in the North‐East Atla...
The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cellsNARA Subscribed
Angiogenesis is largely driven by motile endothelial tip-cells capable of invading avascular tissue domains and enabling new vessel formation. Highly responsive to Vascular Endothelial Growth-Factor-A (VEGFA), endothelial tip-cells also suppress angiogenic sprouting in adjacent stalk cells, and thus have been a primary therapeutic focus in addressing neovascular pathologies. Surprisingly, however, there remains a paucity of sp...