D. Cirillo results 24
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Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolatesNARA Subscribed
Summary Purpose A series of NDM-producing Escherichia coli ST167 clinical isolates exhibiting resistance to cefiderocol (FDC), with no previous exposure to this antibiotic, were analyzed in this study. Methods The antimicrobial susceptibility testing and phenotypic detection of resistance patterns (Rapid Cefiderocol NP test and MIC determination) were performed for all tested isolates. Their entire genomes were sequenced by us...
Modulation of primary motor cortex after experimentally induced and use-dependent plasticity in young and older adultsNARA Subscribed
The ability to induce plasticity in human primary motor cortex (M1) may be diminished with advancing age. Intracortical inhibition is critical for M1 plasticity and regular participation in physical activity can promote M1 plasticity. This study assessed modulation of M1 excitability and inhibition after paired associative stimulation (PAS) and motor skill acquisition in young and older adults, which also considered the cardio...
Molecular analysis of metallo-beta-lactamase-producing Pseudomonas aeruginosa in Switzerland 2022–2023NARA Subscribed
Objectives The occurrence of metallo-beta-lactamase-producing Pseudomonas aeruginosa (MBL-PA) isolates is increasing globally, including in Switzerland. The aim of this study was to characterise, phenotypically and genotypically, the MBL-PA isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) reference laboratory over a 12-month period from July 2022 to July 2023. Methods Thirty-n...
Transcranial magnetic stimulation (TMS) studies typically focus on suprathreshold motor evoked potentials (MEPs), overlooking small MEPs representing subthreshold corticomotor pathway activation. Assessing subthreshold excitability could provide insights into corticomotor pathway integrity and function, particularly in neurological conditions like stroke. The aim of the study was to examine the test–retest reliability of metri...
Comparing anticipatory and stop-signal response inhibition with a novel, open-source selective stopping toolboxNARA Subscribed
Response inhibition is essential for terminating inappropriate actions and, in some cases, may be required selectively. Selective stopping can be investigated with multicomponent anticipatory or stop-signal response inhibition paradigms. Here we provide a freely available open-source Selective Stopping Toolbox (SeleST) to investigate selective stopping using either anticipatory or stop-signal task variants. This study aimed to...
Resting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expressionNARA Subscribed
Pseudobulbar affect (PBA), referring to exaggerated or inappropriate episodes of laughing and/or crying without an apparent motivating stimulus, has been mainly attributed to bilateral degeneration of corticobulbar tracts. We aimed at exploring brain functional connectivity (FC) correlates of PBA in patients with amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, frequently associated with PBA. Resting...
Intracortical facilitation and inhibition in human primary motor cortex during motor skill acquisitionNARA Subscribed
The primary motor cortex (M1) is critical for movement execution, but its role in motor skill acquisition remains elusive. Here, we examine the role of M1 intracortical circuits during skill acquisition. Paired-pulse transcranial magnetic stimulation (TMS) paradigms of short-interval intracortical facilitation (SICF) and inhibition (SICI) were used to assess excitatory and inhibitory circuits, respectively. We hypothesised tha...
Hippocampal connectivity in Amyotrophic Lateral Sclerosis (ALS): more than Papez circuit impairmentNARA Subscribed
Emerging evidence suggests that memory deficit in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with varying impairment of motor abilities and cognitive profile, may be independent from executive dysfunction. Our multimodal magnetic resonance imaging (MRI) approach, including resting state functional MRI (RS-fMRI), diffusion tensor imaging (DTI) and voxel-based morphometry (VBM), aimed to investigate structu...
The prehistoric (< 7 ka) Zaro eruption at Ischia island (Southern Italy) produced a lava complex overlaying a pyroclastic deposit. Although being of low energy, the Zaro eruption might have caused casualties among the neolithic population that inhabited that area of Ischia, and damages to their settlements. A similar eruption at Ischia with its present-day population would turn into a disaster. Therefore, understanding the mag...
Recommendations for the diagnosis of pediatric tuberculosisNARA Subscribed
Germ cell proliferation and apoptosis during different phases of swordfish ( Xiphias gladius L.) spermatogenetic cycleNARA Subscribed
Seasonal changes of testicular activity of the swordfish Xiphias gladius and correlations of plasma levels of testosterone (T) and 11‐ketotestosterone (11‐KT) with proliferation and apoptosis of germ cells, determined, respectively, with monoclonal antibodies against proliferating cell nuclear antigen and terminal deoxynucleotidyl transferase‐mediated d’UTP nick end labelling, are described. Three phases of the reproductive cy...
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