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Background Cardiovascular diseases are the leading cause of death worldwide. An important mechanism involved is the disruption in protein homeostasis by overactivation of the classical axis of the renin-angiotensin system. The counterregulatory axis counteracts these effects; however, the MrgD receptor has recently been described, and its effects are unknown. Thus, this study aims to evaluate the impact of MrgD deficiency on c...
Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat dietNARA Subscribed
Obesity and endocrine disruptors (EDs) promote endoplasmic reticulum (ER) stress, a mechanism associated with cardiovascular diseases. Among EDs, BPS is widely used in consumer products. Whether BPS promotes cardiac ER stress, either alone or combined with a high-fat diet, remains unclear. Male C57BL/6 mice were assigned to a standard chow diet (SC—15 kJ/g), SC+BPS (SCB), high-fat diet (HF—21 kJ/g), or HF+BPS (HFB), receiving...
Environmental stress-associated tissue deterioration remains an important challenge in the cultivation of Kappaphycus alvarezii . This study evaluated the effects of immersion-based application of Origanum vulgare extract on the growth performance and pigmentation of K. alvarezii cultivated under field conditions. In vitro antibacterial assays showed inhibitory activity of the extract against Staphylococcus aureus (21 mm inhib...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Among the main drivers of critical changes in marine environments is global warming, largely caused by anthropogenic activities. Growing evidence suggests that climate change is rapidly and detrimentally impacting ecosystems worldwide, challenging the survival of marine organisms, including corals. We carried out in-situ experiments to assess the effect of seasonal temperature changes on short-term injury responses of immune-r...