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Evaluation of coal combustion residuals in cement systemsNARA Subscribed
The decline in estrogen following menopause is a major driver of metabolic and immune dysfunction in aging females. While hormone replacement therapy improves many of these outcomes, its clinical use remains limited due to concerns regarding estrogen-sensitive malignancies. Tissue-selective estrogen complexes (TSECs), which combine estrogens with selective estrogen receptor modulators (SERMs) such as tamoxifen (TAM), represent...
Food limitation erodes the thermal tolerance of larvae in an ecologically influential marine herbivoreNARA Subscribed
Biologists often use organismal thermal tolerance to help explain or forecast responses of populations to climate change. Yet many studies quantify thermal tolerance under isolated laboratory conditions despite extreme events, such as heatwaves, often coinciding with other stressors such as nutrient or food limitation. These oversights may be consequential as recent theory suggests thermal tolerance itself can be fundamentally...
Genetic diversity is the foundation of biodiversity, and preserving it is therefore fundamental to conservation practice. However, global conservation efforts face significant challenges integrating genetic and genomic approaches into applied management and policy. As collaborative partnerships are increasingly recognized as key components of successful conservation efforts, we explore their role and relevance in the Australia...
The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages,...
Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infectionsNARA Subscribed
Airway epithelium represents a physical barrier against toxic substances and pathogens but also presents pattern recognition receptors on the epithelial cells that detect pathogens leading to molecule release and sending signals that activate both the innate and adaptive immune responses. Thus, impaired airway epithelial function and poor integrity may increase the recurrence of infections. Probiotic use in respiratory disease...